| Oct 5: | Kansas (-10) 52 | at Oklahoma 24 |
| Michigan (-7) 16 | at Northwestern 17 | |
| Michigan State 30 | at Iowa (-8 1/2) 37 | |
| Penn State 7 | at Ohio State (-10) 38 | |
| Nebraska (-13) 39 | at Kansas State 3 | |
| California 22 | at Southern Cal (-16) 15 | |
| Virginia (-7) 7 | at Georgia Tech 13 | |
| Boston College 17 | at West Virginia (-14) 34 | |
| Texas Christian 7 | at Tulane (-2 1/2) 35 | |
| Oct 6: | Green Bay (-8) 37 | at Chicago 6 |
| Carolina 12 | at Minnesota (-6) 14 | |
| Indianapolis 13 | at Buffalo (-2) 16 (ot) | |
| San Diego 17 | at Denver (-3 1/2) 28 | |
| Houston 30 | at Cincinnati (-1) 27 (ot) | |
| Oct 7: | Pittsburgh 17 | at Kansas City (-4 1/2) 7 |