History of San Francisco 49ers
Versus Los Angeles Rams
| 09/12/16 | 0 | 28 | | Won | +2.5 W | 43 U | @ San Francisco, CA |
| 12/24/16 | 22 | 21 | | Won | +6 W | 39.5 O | @ Los Angeles, CA |
| 09/21/17 | 41 | 39 | | Lost | +3 W | 40 O | @ San Francisco, CA |
| 12/31/17 | 34 | 13 | | Won | -6.5 W | 44 O | @ Los Angeles, CA |
| 10/21/18 | 39 | 10 | | Lost | +9 L | 52 U | @ San Francisco, CA |
| 12/30/18 | 32 | 48 | | Lost | +10.5 L | 50 O | @ Los Angeles, CA |
| 10/13/19 | 20 | 7 | | Won | +3 W | 50 U | @ Los Angeles, CA |
| 12/21/19 | 31 | 34 | | Won | -7 L | 45.5 O | @ San Francisco, CA |
| 10/18/20 | 16 | 24 | | Won | +2.5 W | 51 U | @ San Francisco, CA |
| 11/29/20 | 23 | 20 | | Won | +5.5 W | 44.5 U | @ Los Angeles, CA |
| 11/15/21 | 10 | 31 | | Won | +3.5 W | 50 U | @ San Francisco, CA |
| 01/09/22 | 27 | 24 | (ot) | Won | +3.5 W | 46.5 O | @ Los Angeles, CA |
| 01/30/22 | 17 | 20 | | Lost | +3.5 W | 45.5 U | @ Los Angeles, CA |
| 10/03/22 | 9 | 24 | | Won | -1.5 W | 42 U | @ San Francisco, CA |
| 10/30/22 | 31 | 14 | | Won | +1 W | 42.5 O | @ Los Angeles, CA |
| 09/17/23 | 30 | 23 | | Won | -7 T | 45 O | @ Los Angeles, CA |
| 01/07/24 | 21 | 20 | | Lost | -5.5 L | 40.5 O | @ San Francisco, CA |
| 09/22/24 | 24 | 27 | | Lost | -6 L | 44.5 O | @ Los Angeles, CA |
| 12/12/24 | 12 | 6 | | Lost | -3 L | 48.5 U | @ San Francisco, CA |
| totals | | 12-7 | (12-6-1) | |