History of Iowa State Cyclones
Versus Kansas State Wildcats
| 12/03/11 | 23 | 30 | | Lost | | | @ Manhattan, KS |
| 10/13/12 | 27 | 21 | | Lost | | | @ Ames, IA |
| 11/02/13 | 7 | 41 | | Lost | | | @ Manhattan, KS |
| 09/06/14 | 32 | 28 | | Lost | | | @ Ames, IA |
| 11/21/15 | 35 | 38 | | Lost | | | @ Manhattan, KS |
| 10/29/16 | 31 | 26 | | Lost | +6 W | 50.5 O | @ Ames, IA |
| 11/25/17 | 19 | 20 | | Lost | +2.5 W | 50.5 U | @ Manhattan, KS |
| 11/24/18 | 38 | 42 | | Won | -10.5 L | 42 O | @ Ames, IA |
| 11/30/19 | 17 | 27 | | Lost | -5 L | 45.5 U | @ Manhattan, KS |
| 11/21/20 | 0 | 45 | | Won | -13.5 W | 48 U | @ Ames, IA |
| 10/16/21 | 33 | 20 | | Won | -6.5 W | 50.5 O | @ Manhattan, KS |
| 10/08/22 | 10 | 9 | | Lost | pk L | 45 U | @ Ames, IA |
| 11/25/23 | 42 | 35 | | Won | +9.5 W | 46.5 O | @ Manhattan, KS |
| 11/30/24 | 21 | 29 | | Won | -2.5 W | 51.5 U | @ Ames, IA |
| totals | | 5-9 | (6-3) | |