History of Wake Forest Demon Deacons
Versus Clemson Tigers
| 11/12/11 | 28 | 31 | | Lost | | | @ Clemson, SC |
| 10/25/12 | 42 | 13 | | Lost | | | @ Winston-Salem, NC |
| 09/28/13 | 7 | 56 | | Lost | | | @ Clemson, SC |
| 11/06/14 | 34 | 20 | | Lost | | | @ Winston-Salem, NC |
| 11/21/15 | 13 | 33 | | Lost | | | @ Clemson, SC |
| 11/19/16 | 35 | 13 | | Lost | +24 W | 48 T | @ Winston-Salem, NC |
| 10/07/17 | 14 | 28 | | Lost | +21.5 W | 50.5 U | @ Clemson, SC |
| 10/06/18 | 63 | 3 | | Lost | +20.5 L | 61 O | @ Winston-Salem, NC |
| 11/16/19 | 3 | 52 | | Lost | +34.5 L | 59.5 U | @ Clemson, SC |
| 09/12/20 | 37 | 13 | | Lost | +35 W | 59 U | @ Winston-Salem, NC |
| 11/20/21 | 27 | 48 | | Lost | +3.5 L | 56.5 O | @ Clemson, SC |
| 09/24/22 | 51 | 45 | (ot) | Lost | +7.5 W | 58 O | @ Winston-Salem, NC |
| 10/07/23 | 12 | 17 | | Lost | +21 W | 53.5 U | @ Clemson, SC |
| 10/12/24 | 49 | 14 | | Lost | +21 L | 63 T | @ Winston-Salem, NC |
| totals | | 0-14 | (5-4) | |