History of Buffalo Bills
Versus New England Patriots
| 09/25/11 | 31 | 34 | | Won | | | @ Orchard Park, NY |
| 01/01/12 | 21 | 49 | | Lost | | | @ Foxborough, MA |
| 09/30/12 | 52 | 28 | | Lost | | | @ Orchard Park, NY |
| 11/11/12 | 31 | 37 | | Lost | | | @ Foxborough, MA |
| 09/08/13 | 23 | 21 | | Lost | | | @ Orchard Park, NY |
| 12/29/13 | 20 | 34 | | Lost | | | @ Foxborough, MA |
| 10/12/14 | 37 | 22 | | Lost | | | @ Orchard Park, NY |
| 12/28/14 | 17 | 9 | | Won | | | @ Foxborough, MA |
| 09/20/15 | 40 | 32 | | Lost | | | @ Orchard Park, NY |
| 11/23/15 | 13 | 20 | | Lost | | | @ Foxborough, MA |
| 10/02/16 | 16 | 0 | | Won | +3.5 W | 41 U | @ Foxborough, MA |
| 10/30/16 | 41 | 25 | | Lost | +6.5 L | 48.5 O | @ Orchard Park, NY |
| 12/03/17 | 23 | 3 | | Lost | +8 L | 49 U | @ Orchard Park, NY |
| 12/24/17 | 16 | 37 | | Lost | +11 L | 47.5 O | @ Foxborough, MA |
| 10/29/18 | 25 | 6 | | Lost | +14 L | 44.5 U | @ Orchard Park, NY |
| 12/23/18 | 12 | 24 | | Lost | +13.5 W | 45 U | @ Foxborough, MA |
| 09/29/19 | 16 | 10 | | Lost | +7 W | 41.5 U | @ Orchard Park, NY |
| 12/21/19 | 17 | 24 | | Lost | +6.5 L | 39 O | @ Foxborough, MA |
| 11/01/20 | 21 | 24 | | Won | -4.5 L | 41 O | @ Orchard Park, NY |
| 12/28/20 | 38 | 9 | | Won | -7 W | 47 T | @ Foxborough, MA |
| 12/06/21 | 14 | 10 | | Lost | -3 L | 40 U | @ Orchard Park, NY |
| 12/26/21 | 33 | 21 | | Won | +1 W | 43.5 O | @ Foxborough, MA |
| 01/15/22 | 16 | 47 | | Won | -4.5 W | 43 O | @ Orchard Park, NY |
| 12/01/22 | 24 | 10 | | Won | -3.5 W | 44 U | @ Foxborough, MA |
| 01/08/23 | 23 | 35 | | Won | -8.5 W | 43.5 O | @ Orchard Park, NY |
| 10/22/23 | 25 | 29 | | Lost | -7.5 L | 41 O | @ Foxborough, MA |
| 12/31/23 | 21 | 27 | | Won | -15.5 L | 40.5 O | @ Orchard Park, NY |
| totals | | 10-17 | (8-9) | |