History of Arizona Cardinals
Versus San Francisco 49ers
| 11/20/11 | 7 | 23 | | Lost | | | @ San Francisco, CA |
| 12/11/11 | 19 | 21 | | Won | | | @ Glendale, AZ |
| 10/29/12 | 24 | 3 | | Lost | | | @ Glendale, AZ |
| 12/30/12 | 13 | 27 | | Lost | | | @ San Francisco, CA |
| 10/13/13 | 20 | 32 | | Lost | | | @ San Francisco, CA |
| 12/29/13 | 23 | 20 | (ot) | Lost | | | @ Glendale, AZ |
| 09/21/14 | 14 | 23 | | Won | | | @ Glendale, AZ |
| 12/28/14 | 17 | 20 | | Lost | | | @ San Francisco, CA |
| 09/27/15 | 7 | 47 | | Won | | | @ Glendale, AZ |
| 11/29/15 | 19 | 13 | | Won | | | @ San Francisco, CA |
| 10/06/16 | 33 | 21 | | Won | -3.5 W | 42.5 O | @ San Francisco, CA |
| 11/13/16 | 20 | 23 | | Won | -14 L | 47 U | @ Glendale, AZ |
| 10/01/17 | 15 | 18 | (ot) | Won | -6.5 L | 43.5 U | @ Glendale, AZ |
| 11/05/17 | 20 | 10 | | Won | -2.5 W | 39 U | @ San Francisco, CA |
| 10/07/18 | 28 | 18 | | Won | +3 W | 40.5 O | @ San Francisco, CA |
| 10/28/18 | 15 | 18 | | Won | +2.5 W | 40 U | @ Glendale, AZ |
| 10/31/19 | 28 | 25 | | Lost | +10 W | 43.5 O | @ Glendale, AZ |
| 11/17/19 | 26 | 36 | | Lost | +10 T | 44 O | @ San Francisco, CA |
| 09/13/20 | 24 | 20 | | Won | +7 W | 48.5 U | @ San Francisco, CA |
| 12/26/20 | 20 | 12 | | Lost | -6 L | 49 U | @ Glendale, AZ |
| 10/10/21 | 10 | 17 | | Won | -6 W | 48.5 U | @ Glendale, AZ |
| 11/07/21 | 31 | 17 | | Won | +5.5 W | 44.5 O | @ San Francisco, CA |
| 11/21/22 | 38 | 10 | | Lost | +9.5 L | 43 O | @ Mexico City, MX |
| 01/08/23 | 13 | 38 | | Lost | +14.5 L | 40.5 O | @ San Francisco, CA |
| 10/01/23 | 16 | 35 | | Lost | +14.5 L | 44 O | @ San Francisco, CA |
| 12/17/23 | 45 | 29 | | Lost | +12 L | 48.5 O | @ Glendale, AZ |
| totals | | 13-13 | (8-7-1) | |