History of Kansas City Chiefs
Versus Buffalo Bills
| 09/11/11 | 41 | 7 | | Lost | | | @ Kansas City, MO |
| 09/16/12 | 17 | 35 | | Lost | | | @ Orchard Park, NY |
| 11/03/13 | 23 | 13 | | Won | | | @ Orchard Park, NY |
| 11/09/14 | 17 | 13 | | Won | | | @ Orchard Park, NY |
| 11/29/15 | 22 | 30 | | Won | | | @ Kansas City, MO |
| 11/26/17 | 16 | 10 | | Lost | -9 L | 47 U | @ Kansas City, MO |
| 10/19/20 | 26 | 17 | | Won | -5.5 W | 55 U | @ Orchard Park, NY |
| 01/24/21 | 24 | 38 | | Won | -3 W | 55 O | @ Kansas City, MO |
| 10/10/21 | 34 | 20 | | Lost | -3 L | 57 U | @ Kansas City, MO |
| 01/23/22 | 36 | 42 | (ot) | Won | -2.5 W | 54.5 O | @ Kansas City, MO |
| 10/16/22 | 24 | 20 | | Lost | +2.5 L | 54.5 U | @ Kansas City, MO |
| 12/10/23 | 20 | 17 | | Lost | -1.5 L | 49.5 U | @ Kansas City, MO |
| 01/21/24 | 27 | 24 | | Won | +2.5 W | 45.5 O | @ Orchard Park, NY |
| totals | | 7-6 | (4-4) | |