History of San Francisco 49ers
Versus Seattle Seahawks
| 09/11/11 | 17 | 33 | | Won | | | @ San Francisco, CA |
| 12/24/11 | 19 | 17 | | Won | | | @ Seattle, WA |
| 10/18/12 | 6 | 13 | | Won | | | @ San Francisco, CA |
| 12/23/12 | 13 | 42 | | Lost | | | @ Seattle, WA |
| 09/15/13 | 3 | 29 | | Lost | | | @ Seattle, WA |
| 12/08/13 | 17 | 19 | | Won | | | @ San Francisco, CA |
| 01/19/14 | 17 | 23 | | Lost | | | @ Seattle, WA |
| 11/27/14 | 19 | 3 | | Lost | | | @ San Francisco, CA |
| 12/14/14 | 7 | 17 | | Lost | | | @ Seattle, WA |
| 10/22/15 | 20 | 3 | | Lost | | | @ San Francisco, CA |
| 11/22/15 | 13 | 29 | | Lost | | | @ Seattle, WA |
| 09/25/16 | 18 | 37 | | Lost | +10.5 L | 42 O | @ Seattle, WA |
| 01/01/17 | 25 | 23 | | Lost | +11.5 W | 45 O | @ San Francisco, CA |
| 09/17/17 | 9 | 12 | | Lost | +13.5 W | 41 U | @ Seattle, WA |
| 11/26/17 | 24 | 13 | | Lost | +7 L | 45 U | @ San Francisco, CA |
| 12/02/18 | 16 | 43 | | Lost | +9.5 L | 45 O | @ Seattle, WA |
| 12/16/18 | 23 | 26 | (ot) | Won | +4 W | 44 O | @ San Francisco, CA |
| 11/11/19 | 27 | 24 | (ot) | Lost | -6.5 L | 47 O | @ San Francisco, CA |
| 12/29/19 | 26 | 21 | | Won | -3.5 W | 47 T | @ Seattle, WA |
| 11/01/20 | 27 | 37 | | Lost | +1 L | 54.5 O | @ Seattle, WA |
| 01/03/21 | 26 | 23 | | Lost | +7 W | 45 O | @ San Francisco, CA |
| 10/03/21 | 28 | 21 | | Lost | -2.5 L | 52 U | @ San Francisco, CA |
| 12/05/21 | 23 | 30 | | Lost | -2.5 L | 44.5 O | @ Seattle, WA |
| 09/18/22 | 7 | 27 | | Won | -8.5 W | 39.5 U | @ San Francisco, CA |
| 12/15/22 | 21 | 13 | | Won | -3 W | 42.5 U | @ Seattle, WA |
| 01/14/23 | 23 | 41 | | Won | -9.5 W | 42.5 O | @ San Francisco, CA |
| 11/23/23 | 31 | 13 | | Won | -7.5 W | 43.5 O | @ Seattle, WA |
| 12/10/23 | 16 | 28 | | Won | -13.5 L | 45.5 U | @ San Francisco, CA |
| totals | | 11-17 | (9-8) | |