History of Houston Texans
Versus Jacksonville Jaguars
| 10/30/11 | 14 | 24 | | Won | | | @ Houston, TX |
| 11/27/11 | 20 | 13 | | Won | | | @ Jacksonville, FL |
| 09/16/12 | 27 | 7 | | Won | | | @ Jacksonville, FL |
| 11/18/12 | 37 | 43 | (ot) | Won | | | @ Houston, TX |
| 11/24/13 | 13 | 6 | | Lost | | | @ Houston, TX |
| 12/05/13 | 20 | 27 | | Lost | | | @ Jacksonville, FL |
| 12/07/14 | 27 | 13 | | Won | | | @ Jacksonville, FL |
| 12/28/14 | 17 | 23 | | Won | | | @ Houston, TX |
| 10/18/15 | 31 | 20 | | Won | | | @ Jacksonville, FL |
| 01/03/16 | 6 | 30 | | Won | | | @ Houston, TX |
| 11/13/16 | 24 | 21 | | Won | +3 W | 42.5 O | @ Jacksonville, FL |
| 12/18/16 | 20 | 21 | | Won | -3.5 L | 39.5 O | @ Houston, TX |
| 09/10/17 | 29 | 7 | | Lost | -6 L | 38 U | @ Houston, TX |
| 12/17/17 | 7 | 45 | | Lost | +10.5 L | 39.5 O | @ Jacksonville, FL |
| 10/21/18 | 20 | 7 | | Won | +3.5 W | 42.5 U | @ Jacksonville, FL |
| 12/30/18 | 3 | 20 | | Won | -7 W | 39.5 U | @ Houston, TX |
| 09/15/19 | 12 | 13 | | Won | -7 L | 43 U | @ Houston, TX |
| 11/03/19 | 26 | 3 | | Won | +1 W | 46 U | @ London(W), UK |
| 10/11/20 | 14 | 30 | | Won | -6.5 W | 54.5 U | @ Houston, TX |
| 11/08/20 | 27 | 25 | | Won | -7 L | 49 O | @ Jacksonville, FL |
| 09/12/21 | 21 | 37 | | Won | +3 W | 45.5 O | @ Houston, TX |
| 12/19/21 | 30 | 16 | | Won | +6 W | 40 O | @ Jacksonville, FL |
| 10/09/22 | 13 | 6 | | Won | +7 W | 43.5 U | @ Jacksonville, FL |
| 01/01/23 | 31 | 3 | | Lost | +3.5 L | 43.5 U | @ Houston, TX |
| 09/24/23 | 37 | 17 | | Won | +7.5 W | 43.5 O | @ Jacksonville, FL |
| 11/26/23 | 24 | 21 | | Lost | +1.5 L | 47.5 U | @ Houston, TX |
| totals | | 20-6 | (9-7) | |