History of New England Patriots
Versus Buffalo Bills
| 09/25/11 | 31 | 34 | | Lost | | | @ Orchard Park, NY |
| 01/01/12 | 21 | 49 | | Won | | | @ Foxborough, MA |
| 09/30/12 | 52 | 28 | | Won | | | @ Orchard Park, NY |
| 11/11/12 | 31 | 37 | | Won | | | @ Foxborough, MA |
| 09/08/13 | 23 | 21 | | Won | | | @ Orchard Park, NY |
| 12/29/13 | 20 | 34 | | Won | | | @ Foxborough, MA |
| 10/12/14 | 37 | 22 | | Won | | | @ Orchard Park, NY |
| 12/28/14 | 17 | 9 | | Lost | | | @ Foxborough, MA |
| 09/20/15 | 40 | 32 | | Won | | | @ Orchard Park, NY |
| 11/23/15 | 13 | 20 | | Won | | | @ Foxborough, MA |
| 10/02/16 | 16 | 0 | | Lost | -3.5 L | 41 U | @ Foxborough, MA |
| 10/30/16 | 41 | 25 | | Won | -6.5 W | 48.5 O | @ Orchard Park, NY |
| 12/03/17 | 23 | 3 | | Won | -8 W | 49 U | @ Orchard Park, NY |
| 12/24/17 | 16 | 37 | | Won | -11 W | 47.5 O | @ Foxborough, MA |
| 10/29/18 | 25 | 6 | | Won | -14 W | 44.5 U | @ Orchard Park, NY |
| 12/23/18 | 12 | 24 | | Won | -13.5 L | 45 U | @ Foxborough, MA |
| 09/29/19 | 16 | 10 | | Won | -7 L | 41.5 U | @ Orchard Park, NY |
| 12/21/19 | 17 | 24 | | Won | -6.5 W | 39 O | @ Foxborough, MA |
| 11/01/20 | 21 | 24 | | Lost | +4.5 W | 41 O | @ Orchard Park, NY |
| 12/28/20 | 38 | 9 | | Lost | +7 L | 47 T | @ Foxborough, MA |
| 12/06/21 | 14 | 10 | | Won | +3 W | 40 U | @ Orchard Park, NY |
| 12/26/21 | 33 | 21 | | Lost | -1 L | 43.5 O | @ Foxborough, MA |
| 01/15/22 | 16 | 47 | | Lost | +4.5 L | 43 O | @ Orchard Park, NY |
| 12/01/22 | 24 | 10 | | Lost | +3.5 L | 44 U | @ Foxborough, MA |
| 01/08/23 | 23 | 35 | | Lost | +8.5 L | 43.5 O | @ Orchard Park, NY |
| 10/22/23 | 25 | 29 | | Won | +7.5 W | 41 O | @ Foxborough, MA |
| 12/31/23 | 21 | 27 | | Lost | +15.5 W | 40.5 O | @ Orchard Park, NY |
| totals | | 17-10 | (9-8) | |