History of Kansas State Wildcats
Versus Iowa State Cyclones
| 12/03/11 | 23 | 30 | | Won | | | @ Manhattan, KS |
| 10/13/12 | 27 | 21 | | Won | | | @ Ames, IA |
| 11/02/13 | 7 | 41 | | Won | | | @ Manhattan, KS |
| 09/06/14 | 32 | 28 | | Won | | | @ Ames, IA |
| 11/21/15 | 35 | 38 | | Won | | | @ Manhattan, KS |
| 10/29/16 | 31 | 26 | | Won | -6 L | 50.5 O | @ Ames, IA |
| 11/25/17 | 19 | 20 | | Won | -2.5 L | 50.5 U | @ Manhattan, KS |
| 11/24/18 | 38 | 42 | | Lost | +10.5 W | 42 O | @ Ames, IA |
| 11/30/19 | 17 | 27 | | Won | +5 W | 45.5 U | @ Manhattan, KS |
| 11/21/20 | 0 | 45 | | Lost | +13.5 L | 48 U | @ Ames, IA |
| 10/16/21 | 33 | 20 | | Lost | +6.5 L | 50.5 O | @ Manhattan, KS |
| 10/08/22 | 10 | 9 | | Won | pk W | 45 U | @ Ames, IA |
| 11/25/23 | 42 | 35 | | Lost | -9.5 L | 46.5 O | @ Manhattan, KS |
| totals | | 9-4 | (3-5) | |