History of Louisville Cardinals
Versus Kentucky Wildcats
| 09/17/11 | 24 | 17 | | Won | | | @ Lexington, KY |
| 09/02/12 | 14 | 32 | | Won | | | @ Louisville, KY |
| 09/14/13 | 27 | 13 | | Won | | | @ Lexington, KY |
| 11/29/14 | 40 | 44 | | Won | | | @ Louisville, KY |
| 11/28/15 | 38 | 24 | | Won | | | @ Lexington, KY |
| 11/26/16 | 41 | 38 | | Lost | -28 L | 70.5 O | @ Louisville, KY |
| 11/25/17 | 44 | 17 | | Won | -10 W | 68 U | @ Lexington, KY |
| 11/24/18 | 56 | 10 | | Lost | +17 L | 53 O | @ Louisville, KY |
| 11/30/19 | 13 | 45 | | Lost | +3.5 L | 51.5 O | @ Lexington, KY |
| 11/27/21 | 52 | 21 | | Lost | -3 L | 57.5 O | @ Louisville, KY |
| 11/26/22 | 13 | 26 | | Lost | +3.5 L | 42.5 U | @ Lexington, KY |
| 11/25/23 | 38 | 31 | | Lost | -7.5 L | 47.5 O | @ Louisville, KY |
| totals | | 6-6 | (1-6) | |