History of Virginia Cavaliers
Versus Louisville Cardinals
| 09/13/14 | 21 | 23 | | Won | | | @ Charlottesville, VA |
| 11/14/15 | 31 | 38 | | Lost | | | @ Louisville, KY |
| 10/29/16 | 32 | 25 | | Lost | +33 W | 70 U | @ Charlottesville, VA |
| 11/11/17 | 21 | 38 | | Lost | +14 L | 66 U | @ Louisville, KY |
| 09/22/18 | 3 | 27 | | Won | -4.5 W | 53 U | @ Charlottesville, VA |
| 10/26/19 | 21 | 28 | | Lost | -3.5 L | 51.5 U | @ Louisville, KY |
| 11/14/20 | 17 | 31 | | Won | -6 W | 63.5 U | @ Charlottesville, VA |
| 10/09/21 | 34 | 33 | | Won | +2.5 W | 69.5 U | @ Louisville, KY |
| 10/08/22 | 34 | 17 | | Lost | -1.5 L | 47.5 O | @ Charlottesville, VA |
| 11/09/23 | 24 | 31 | | Lost | +20.5 W | 49.5 O | @ Louisville, KY |
| totals | | 4-6 | (5-3) | |