History of T.C.U. Horned Frogs
Versus Iowa State Cyclones
| 10/06/12 | 37 | 23 | | Lost | | | @ Fort Worth, TX |
| 11/09/13 | 21 | 17 | | Won | | | @ Ames, IA |
| 12/06/14 | 3 | 55 | | Won | | | @ Fort Worth, TX |
| 10/17/15 | 45 | 21 | | Won | | | @ Ames, IA |
| 09/17/16 | 20 | 41 | | Won | -25 L | 59.5 O | @ Fort Worth, TX |
| 10/28/17 | 7 | 14 | | Lost | -7 L | 48.5 U | @ Ames, IA |
| 09/29/18 | 14 | 17 | | Won | -11.5 L | 45 U | @ Fort Worth, TX |
| 10/05/19 | 24 | 49 | | Lost | +3 L | 45 O | @ Ames, IA |
| 09/26/20 | 37 | 34 | | Lost | +4 W | 43 O | @ Fort Worth, TX |
| 11/26/21 | 14 | 48 | | Lost | +15 L | 61 O | @ Ames, IA |
| 11/26/22 | 14 | 62 | | Won | -9.5 W | 46.5 O | @ Fort Worth, TX |
| 10/07/23 | 14 | 27 | | Lost | -6.5 L | 52.5 U | @ Ames, IA |
| totals | | 6-6 | (2-6) | |