History of Prairie View A&M Panthers
Versus Texas Southern Tigers
| 09/10/11 | 37 | 34 | | Won | | | @ Houston, TX |
| 09/01/12 | 41 | 44 | | Lost | | | @ Houston, TX |
| 08/31/13 | 37 | 13 | | Won | | | @ Houston, TX |
| 08/31/14 | 35 | 37 | | Lost | | | @ Houston, TX |
| 09/05/15 | 38 | 11 | | Won | | | @ Houston, TX |
| 09/04/16 | 25 | 29 | | Won | | | @ Prairie View, TX |
| 11/25/17 | 30 | 16 | | Won | | | @ Houston, TX |
| 11/24/18 | 14 | 60 | | Won | -17 W | 52 O | @ Prairie View, TX |
| 08/31/19 | 44 | 23 | | Won | -15.5 W | 57.5 O | @ Houston, TX |
| 03/06/21 | 19 | 20 | | Won | | | @ Prairie View, TX |
| 09/04/21 | 40 | 17 | | Won | -10.5 W | 57.5 U | @ Houston, TX |
| 09/03/22 | 23 | 40 | | Won | | | @ Prairie View, TX |
| 09/02/23 | 37 | 34 | (ot) | Won | | | @ Houston, TX |
| totals | | 11-2 | (3-0) | |