History of Clemson Tigers
Versus Florida State Seminoles
| 09/24/11 | 30 | 35 | | Won | | | @ Clemson, SC |
| 09/22/12 | 37 | 49 | | Lost | | | @ Tallahassee, FL |
| 10/19/13 | 51 | 14 | | Lost | | | @ Clemson, SC |
| 09/20/14 | 17 | 23 | | Lost | | | @ Tallahassee, FL |
| 11/07/15 | 13 | 23 | | Won | | | @ Clemson, SC |
| 10/29/16 | 37 | 34 | | Won | -4.5 L | 59 O | @ Tallahassee, FL |
| 11/11/17 | 14 | 31 | | Won | -16.5 W | 45 T | @ Clemson, SC |
| 10/27/18 | 59 | 10 | | Won | -18 W | 49.5 O | @ Tallahassee, FL |
| 10/12/19 | 14 | 45 | | Won | -26 W | 61 U | @ Clemson, SC |
| 10/30/21 | 20 | 30 | | Won | -9.5 W | 47 O | @ Clemson, SC |
| 10/15/22 | 34 | 28 | | Won | -4.5 W | 51 O | @ Tallahassee, FL |
| 09/23/23 | 31 | 24 | (ot) | Lost | +2 L | 55.5 U | @ Clemson, SC |
| 10/05/24 | 29 | 13 | | Won | -16.5 L | 47.5 U | @ Tallahassee, FL |
| totals | | 9-4 | (5-3) | |