| Thursday, Dec 14 | 7:15 PM | L.A. Chargers | 36.5 | 21 | |
| Las Vegas | -3.5 | 63 | |||
| Saturday, Dec 16 | 12:00 PM | Minnesota | 41.5 | 24 | |
| Cincinnati | -3.5 | 27 | (ot) | ||
| 3:30 PM | Pittsburgh | 41.5 | 13 | ||
| Indianapolis | -1.5 | 30 | |||
| 7:15 PM | Denver | 49.5 | 17 | ||
| Detroit | -5.5 | 42 | |||
| Sunday, Dec 17 | 12:00 PM | Chicago | 37.5 | 17 | |
| Cleveland | -2.5 | 20 | |||
| 12:00 PM | Kansas City | -10.5 | 27 | ||
| New England | 39.5 | 17 | |||
| 12:00 PM | Atlanta | -2.5 | 7 | ||
| Carolina | 32.5 | 9 | |||
| 12:00 PM | Tampa Bay | 41.5 | 34 | ||
| Green Bay | -3.5 | 20 | |||
| 12:00 PM | Houston | 38.5 | 19 | ||
| Tennessee | -3.5 | 16 | (ot) | ||
| 12:00 PM | N.Y. Jets | 36.5 | 0 | ||
| Miami | -7.5 | 30 | |||
| 12:00 PM | N.Y. Giants | 39.5 | 6 | ||
| New Orleans | -6.5 | 24 | |||
| 3:05 PM | Washington | 49.5 | 20 | ||
| L.A. Rams | -6.5 | 28 | |||
| 3:05 PM | San Francisco | -12 | 45 | ||
| Arizona | 48.5 | 29 | |||
| 3:25 PM | Dallas | 49.5 | 10 | ||
| Buffalo | -2.5 | 31 | |||
| 7:20 PM | Baltimore | -4 | 23 | ||
| Jacksonville | 42.5 | 7 | |||
| Monday, Dec 18 | 7:15 PM | Philadelphia | -4.5 | 17 | |
| Seattle | 47.5 | 20 | |||