| Thursday, Dec 28 | 7:15 PM | N.Y. Jets at Cleveland |
| Cleveland by 9.98 | ||
| Saturday, Dec 30 | 7:15 PM | Detroit at Dallas |
| Dallas by 4.75 | ||
| Sunday, Dec 31 | 12:00 PM | New England at Buffalo |
| Buffalo by 11.98 | ||
| 12:00 PM | Atlanta at Chicago | |
| Chicago by 4.79 | ||
| 12:00 PM | Las Vegas at Indianapolis | |
| Las Vegas by 2.58 | ||
| 12:00 PM | L.A. Rams at N.Y. Giants | |
| L.A. Rams by 3.45 | ||
| 12:00 PM | Arizona at Philadelphia | |
| Philadelphia by 10.49 | ||
| 12:00 PM | New Orleans at Tampa Bay | |
| Tampa Bay by 6.76 | ||
| 12:00 PM | San Francisco at Washington | |
| San Francisco by 14.62 | ||
| 12:00 PM | Carolina at Jacksonville | |
| Jacksonville by 9.53 | ||
| 12:00 PM | Miami at Baltimore | |
| Baltimore by 10.67 | ||
| 12:00 PM | Tennessee at Houston | |
| Houston by 2.48 | ||
| 3:05 PM | Pittsburgh at Seattle | |
| Seattle by 4.69 | ||
| 3:25 PM | L.A. Chargers at Denver | |
| Denver by 5.21 | ||
| 3:25 PM | Cincinnati at Kansas City | |
| Kansas City by 4.26 | ||
| 7:20 PM | Green Bay at Minnesota | |
| Minnesota by 3.88 | ||