| Thursday, Dec 19 | 7:15 PM | Denver at L.A. Chargers |
| Denver by 2.63 | ||
| Saturday, Dec 21 | 11:00 AM | South Dakota State at North Dakota State |
| South Dakota State by 0.55 | ||
| 12:00 PM | Houston at Kansas City | |
| Kansas City by 4.48 | ||
| 2:30 PM | South Dakota at Montana State | |
| Montana State by 5.04 | ||
| 3:30 PM | Pittsburgh at Baltimore | |
| Baltimore by 6.35 | ||
| Sunday, Dec 22 | 12:00 PM | N.Y. Giants at Atlanta |
| Atlanta by 8.66 | ||
| 12:00 PM | Detroit at Chicago | |
| Detroit by 11.35 | ||
| 12:00 PM | Tennessee at Indianapolis | |
| Indianapolis by 7.43 | ||
| 12:00 PM | L.A. Rams at N.Y. Jets | |
| L.A. Rams by 1.74 | ||
| 12:00 PM | Philadelphia at Washington | |
| Philadelphia by 6.10 | ||
| 12:00 PM | Arizona at Carolina | |
| Arizona by 5.66 | ||
| 12:00 PM | Cleveland at Cincinnati | |
| Cincinnati by 10.65 | ||
| 3:05 PM | Minnesota at Seattle | |
| Seattle by 0.06 | ||
| 3:25 PM | Jacksonville at Las Vegas | |
| Las Vegas by 0.18 | ||
| 3:25 PM | San Francisco at Miami | |
| Miami by 2.45 | ||
| 3:25 PM | New England at Buffalo | |
| Buffalo by 19.03 | ||
| 7:20 PM | Tampa Bay at Dallas | |
| Tampa Bay by 5.07 | ||
| Monday, Dec 23 | 7:15 PM | New Orleans at Green Bay |
| Green Bay by 16.12 | ||